Dr. Chen Wang

Dr. Chen Wang is a hematopathologist and Head, Division of Hematology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital. He is an Associate Professor, Lab Medicine and Pathobiology, University of Toronto.

He obtained his medical degree from Harbin Medical University, China, and his PhD from the University of Toronto.

His research is focused mainly on lymphocytic neoplasms. In studies of clinical lymphocytosis with flow cytometry and molecular clonality assay, his studies have demonstrated that clonal expansion of B- and T-cell clonopathy. His team also developed a direct lysis PCR method for clonality detection, increasing detection of B cell lymphoma in small or body fluid samples.

Dr. Wang led a team that identified breakpoint sequences linking CDK/6 and IGK genes in a monoclonal B lymphocytosis, and later pinpointed these sequences in a range of clinical B-cell malignancies. This genetic overlap points to deregulation of CDK6 as a common molecular mechanism in clonal B-cell proliferation.

His studies also provided the first identification of a non-CLL type CD5-negative clonal lymphocytosis, now recognized as a unique type of monoclonal B lymphocytosis and included in diagnosis guidelines for this disease.

In collaboration with investigators at the University of Toronto, Dr. Wang developed Raman nanoparticles targeting leukemia cells and developed a flow cytometry method to assess this, and achieved triplex Raman nanoparticle labelling of leukemia cells.

He holds visiting professorships at Beijing University Stem Cell Center and at Harbin Medical University, China.