Dr. Daniel Drucker

OC, MD, FRSC, FRS
Senior Investigator

Lunenfeld-Tanenbaum Research Institute

Peptide hormone biology and therapeutic translation

Our team studies peptide hormones produced in the pancreas, gastrointestinal tract and brain. Controlling blood glucose and insulin secretion, these hormones also regulate our appetite, the absorption of nutrients from the food we eat and the conversion of those nutrients to energy. Our work on the physiology and molecular biology of glucagon-like peptides have continuously advanced the science of peptide hormones and our understanding of their therapeutic potential. Our work has underpinned the development of two classes of medicine for type 2 diabetes (GLP-1 receptor agonists and DPP-4 inhibitors). 

We have also led the identification of the cardioprotective mechanisms of GLP-1 action, predicting the safety of GLP-1 receptor agonists for treatment of obesity and other chronic conditions. Most recently, we have identified multiple mechanisms linking GLP-1 to the reduction of inflammation and the complications associated with type 2 diabetes and obesity. Our scientific discoveries have resulted in 33 US patents supporting translational drug development efforts in the field of peptide-based therapeutics.  

Telephone
Contact

Email: [email protected]

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Location

Room 5-1004, 25 Orde Street
Toronto, M5T 3H7

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Related links

Website: Drucker Lab
Publications: PubMed
Google Scholar: Daniel Drucker
ORCID: 0000-0001-6688-8127
U of T Discover Research: Daniel Drucker
Wikipedia: Daniel Drucker 

Bluesky: @danieljdrucker.bsky.social
X: @DanielJDrucker

Accordion Items
  • 2023–present; University Professor, University of Toronto, Toronto
  • 2006–present; Senior Investigator, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto
  • 1997–present; Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto
  • 1996–present; Professor, Department of Medicine, University of Toronto, Toronto

Former appointments

  • 2000–2011; Director, Banting and Best Diabetes Centre, University of Toronto, Toronto
  • 1992–2001; Director, Division of Endocrinology, Department of Medicine, University of Toronto, Toronto
  • Staff Physician, Toronto General Hospital; 1987–2021
  • Research Fellow in Medicine, Massachusetts General Hospital, Harvard University, Boston; 1984–1987
  • Fellow in Medicine, John Hopkin’s Hospital, Baltimore, Maryland; 1980–1981
  • MD, University of Toronto, Ontario; 1976–1980 
  • 2025 – The Fred Conrad Koch Lifetime Achievement Award, The Endocrine Society
  • 2025 – The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine
  • 2025 – American Association of Clinical Endocrinology Kahn-Tan-Faiman Frontiers in Science and Endocrinology Award
  • 2025 – The Breakthrough Prize in Life Sciences and Medicine
  • 2025 – The 2025 Warren Triennial Prize, Massachusetts General Hospital
  • 2025 – AACR-Irving Weinstein Foundation Distinguished Lectureship Award, American Association for Cancer Research
  • 2025 – The BBVA Frontiers of Knowledge Award in Biology and Biomedicine
  • 2024 – The TOPS Research Achievement Award, The Obesity Society
  • 2024 – The Princess Asturias Award for Technical and Scientific Research
  • 2023 – The VinFuture Prize for innovators with outstanding achievements in emerging fields
  • 2023 – Elected to the National Academy of Medicine (USA)
  • 2023 – The Wolf Prize in Medicine
  • 2022 – Inducted into the Canadian Medical Hall of Fame
  • 2021 – Elected to the National Academy of Sciences, USA
  • 2021 – Canada Gairdner International Award for Biomedical Science

Research opportunities are available for both graduate students and research fellows on an ongoing basis in the Drucker laboratory.

Postdocs 
Our research group is always interested in recruiting highly motivated postdoctoral fellows with a strong publication record in metabolism and physiology. Prior experience with mouse physiology preferred. Please forward your CV, references and research interests to Dr. Daniel Drucker at [email protected].

Graduate students 
Graduate students must apply through the University of Toronto School of Graduate Studies, via a specific graduate Department such as the Institute of Medical Sciences or the Department of Laboratory Medicine and Pathobiology, which requires that a supervisor be identified before admission to the graduate program. Graduate students interested in doing a PhD in the laboratory/group should first contact Dr. Daniel Drucker at [email protected].  

Notable publications

GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice

Nature Metabolism, 2025

Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice

Journal of Clinical Investigation, 2024

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation

Cell Metabolism, 2024

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction

Molecular Metabolism, 2022

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

Cell Metabolism, 2022

Join our team

Visit our job board to see research positions.