Dr. Daniel Durocher

Genomic instability, DNA damage response and cancer therapeutics

The major objective of the work done in our laboratory is to understand the molecular processes by which cells preserve the stability of their entire DNA – their genome– and to use this knowledge to develop therapeutic strategies, particularly for cancer treatment. 

We investigate how cells sense, signal and repair DNA damage, and how defects in these pathways contribute to disease. To address these questions, we use a broad range of approaches, including genetic, biochemical, functional genomic and proteomic methods. We employ the gene editing tool, CRISPR, to systematically inactivate genes in cancer cells. This allows us to identify genes and molecular processes that are essential for the growth of cancer cells, but not healthy cells and which could therefore be targeted for therapy. 

Our research has provided insights into the DNA damage response processes and has revealed targets that can selectively kill cancer cells with specific DNA repair defects. A key goal for our team is to translate these findings into therapeutic approaches. We have engaged in multiple successful collaborations with industrial partners to accelerate this process, bridging fundamental research and translation.