Dr. Jordan Lerner-Ellis
Director & Head, Advanced Molecular Diagnostics, Department of Pathology and Laboratory Medicine (Diagnostic Medical Genetics), Mount Sinai Hospital
Our focus is on advancing genomic diagnostics as a routine part of clinical care. We have driven progress in two key areas: developing national-scale infrastructure, including the Canadian Genomic Data Commons and Pan-Canadian Genome Library, and implementing practices that enhance data acquisition and sharing across Canada and internationally. Based at Mount Sinai Hospital’s Advanced Molecular Diagnostics Laboratory in the Division of Diagnostic Medical Genetics, we integrate clinical services with research discovery, using real-world feedback to refine diagnostic workflows, evaluate test performance, and assess the impact of genomic testing on patient care and disease risk.
We are also improving the sensitivity of genetic testing by adopting new sequencing technologies and developing frameworks to identify genetic disorders. In parallel, we are discovering new disease genes and clinically relevant variants, including through genome sequencing studies in patients to inform better therapies.
This work matters because more accurate and timely diagnoses can guide treatment, enable prevention, and improve outcomes. By strengthening data infrastructure and clinical integration, we are helping bring precision medicine into everyday healthcare.
Email: [email protected]
- 2025–present; Professor, Laboratory Medicine and Pathobiology, University of Toronto, Toronto
- 2016–present; Clinician scientist, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto
- 2011–present; Director & Head, Advanced Molecular Diagnostics, Division of Diagnostic Medical Genetics, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto
- 2011–present; Affiliate, Familial Gastrointestinal Cancer Registry (FGICR), Mount Sinai Hospital, Sinai Health, Toronto
Former appointments
- 2018–2025; Associate professor, Laboratory Medicine and Pathobiology, University of Toronto, Toronto
- 2011–2018; Assistant professor, Laboratory Medicine and Pathobiology, University of Toronto, Toronto
- Clinical molecular fellowship, ABMG Clinical Molecular Genetics Training Program, Harvard Medical School, Boston, MA, USA; 2009–2011
- Clinical fellowship, Partners Center for Personalized Genetic Medicine & Laboratory for Molecular Medicine, Brigham and Women’s Hospital & Harvard Medical School, Boston, MA, USA; 2009– 2011
- Postdoctoral fellowship, Broad Institute of MIT & Harvard and Massachusetts General Hospital, Cambridge, MA, USA, 2007–2009
- Postdoctoral fellowship, Metabolic unit, Universistät Kinderspitäl Beiter Basel, Basel-Landschaft (de), Switzerland; 2006–2007
- PhD, Human genetics, Division of Medical Genetics, McGill University Health Centre & Genome Quebec Innovation Center, McGill University, Montreal, Canada; 2002–2007
- BSc, Biology (Molecular), Concordia University, Montreal, Canada, 1996–2001
- 2025 – Distinguished fellow, Faculty of Medicine, The Hebrew University of Jerusalem, Mt Scopus, Jerusalem, Israel
- 2023–present – Associate fellow, Canadian College of Medical Genetics, Toronto, Canada
- 2011–present – Fellow, American College of Medical Genetics, Boston, MA, USA
- 2011–present – Diplomate, American Board of Medical Genetics, Boston, MA, USA
Notable publications
Genetics in Medicine Open, 2026
American Journal of Human Genetics, 2025
The New England Journal of Medicine, 2024
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