Dr. Ravi

MD, FRCPC
Clinician Scientist

Department of Medicine (Endocrinology), Mount Sinai Hospital

Our clinical research program focuses on understanding the development of type 2 diabetes (T2DM) and gestational diabetes (GDM), a form of diabetes that occurs during pregnancy and predicts future T2DM, and studying treatments for these conditions. This international research program involves clinical trials and prospective observational cohort studies in which women with and without GDM are followed before, during and after pregnancy. Because GDM can be an early sign of T2DM, studying these patients helps us understand how diabetes begins and progresses. 

We also conduct clinical trials aimed at slowing down or reversing the progressive deterioration in the function of pancreatic beta-cells, which produce insulin. This deterioration is a key part of what causes both GDM and T2DM. In this context, we have a particular interest in better understanding the mechanism through which beta-cell dysfunction can be reversed early in diabetes, as this opens the door to the possibility of inducing remission of diabetes. 

In addition, our research program has revealed that how a woman’s body handles blood sugar during pregnancy can provide unique insight into her future risks of diabetes and heart disease. This insight can provide us with an important opportunity to intervene early in order to prevent these conditions before they start.  

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Location

Room L5-025, 60 Murray Street 
Toronto, M5T 3L9

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Related links

Publications: PubMed 
ORCID: 0000-0003-1989-027X

Accordion Items
  • 2017–present; Professor of Medicine, Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto
  • 2009–present; Associate Member, Institute of Medical Sciences, University of Toronto, Toronto
  • 2006–present; Clinician-Scientist, Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, Sinai Health, Toronto

Former appointments 

  • 2012–2017; Associate Professor, Division of Endocrinology and Metabolism, University of Toronto, Toronto
  • 2006–2012; Assistant Professor, Division of Endocrinology and Metabolism, University of Toronto, Toronto 
  • FRCPC, University of Toronto, Toronto; 1999–2003
  • MD, University of Toronto, Toronto; 1994–1999
  • MSc, University of Toronto, Toronto; 1992–1994
  • BMath, University of Toronto, Toronto; 1987–1992
  • 2022 – International Diabetes Federation (IDF) Diabetes in Women Award  
  • 2020 – Fellow of the Canadian Academy of Health Sciences (CAHS)
  • 2014 – Joe Doupe Young Investigator Award, Canadian Society of Clinical 
              Investigation (CSCI)
  • 2013 – Dr. Charles Hollenberg Young Investigator Award, Canadian Society of  
              Endocrinology and Metabolism (CSEM) 

This research program consists of the following studies: 

Toronto Gestational Glucose Tolerance Cohort 

In this long-term prospective observational cohort study, women across the full spectrum of glucose tolerance in pregnancy (from normal glucose tolerance to mild dysglycemia to gestational diabetes (GDM)) are being followed with serial cardiometabolic characterization for over a decade after delivery to study early events in the natural history of type 2 diabetes (T2DM) and cardiovascular disease.

Funded by the Canadian Institutes of Health Research (CIHR). 

Preconception Cohort 

In this prospective observational cohort study that is taking place in China, a cohort of women previously recruited prior to their first pregnancy are undergoing cardiometabolic characterization, along with their partners and their children, a decade after delivery to evaluate the relationships between preconception maternal and paternal health and offspring development at 10 years of age. 

Funded by the Canadian Institutes of Health Research (CIHR). 

HeLTI GDM South Africa

This randomized controlled trial that is taking place in South Africa seeks to determine if preconception lifestyle intervention can reduce the incidence of GDM in young women.

Learn more about HeLTI South Africa trial.

Funded by the Canadian Institutes of Health Research (CIHR). 

HeLTI GDM Canada 

This randomized controlled trial that is taking place across Canada seeks to determine if preconception lifestyle intervention can reduce the incidence of GDM in young women.

Learn more about HeLTI Canada trial

Funded by the Canadian Institutes of Health Research (CIHR). 

HeLTI GDM India 

This randomized controlled trial that is taking place in India seeks to determine if preconception lifestyle intervention can reduce the incidence of GDM in young women. 

Learn more about HeLTI India trial.  

Funded by the Canadian Institutes of Health Research (CIHR). 

Elucidation of the individualized response to an 8-year lifestyle intervention aimed at reducing cardiometabolic risk in young women before, during and after pregnancy 

This team grant seeks to evaluate the lipidomic, metabolomic and proteomic determinants of the impact of peripartum lifestyle intervention on the risk of women developing pre-diabetes or diabetes within the first 5-years after pregnancy.

Funded by the Canadian Institutes of Health Research (CIHR). 

Biomarkers of Beta-cell Function (Diabetes Canada)

In this proteomic profiling study, we seek to identify biomarkers of the reversibility of beta-cell dysfunction and the capacity for sustained preservation of function over 2 years in early type 2 diabetes. 
 
Funded by Diabetes Canada. 
 

Notable publications

The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada

The Lancet Diabetes & Endocrinology, 2025

One-hour oral glucose tolerance test for the postpartum reclassification of women with hyperglycemia in pregnancy

Diabetes Care, 2025

A glycemic threshold above which the improvement of beta-cell function and glycemia in response to insulin therapy is amplified in early type 2 diabetes: the reversal of glucotoxicity

Diabetes Care, 2024

Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes

Nature Communications, 2023

The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial

Nature Communications, 2022